NFL picks, predictions against the spread Week 1: Seahawks flex on Patriots, Rams stop 49ers, Giants stun Cowboys
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What happened
In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.
Summary assembled by rule from the sources below