College football picks: LSU defense will be difference against Ole Miss in weekend's showcase game
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No. 22 Houston's visit to No. 13 Texas Tech gets the spotlight in the Big 12 on Friday night, and No. 16 SMU's game at No. 23 Louisville presumably will help clarify which is the second-best team in the ACC behind Miami. The 17 other Top 25 teams playing Football Bowl Subdivision opponents this weekend are favored by an average of 28.5 points, and only four of those teams are favored by less than three touchdowns.
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